منابع مشابه
Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats
This study examined whether control of hyperglycemia with a new SGLT2 inhibitor, luseogliflozin, given alone or in combination with lisinopril could prevent the development of renal injury in diabetic Dahl salt-sensitive (Dahl S) rats treated with streptozotocin (Dahl-STZ). Blood glucose levels increased from normoglycemic to hyperglycemic levels after treatment of STZ in Dahl S rats. Chronic t...
متن کاملMechanism of Action of Sglt2-inhibitors
T2DM individuals manifest a 2-3 times greater risk of CV events compared to non-diabetics, and CV mortality is responsible for ~70% of total mortality. In T2DM patients without MI, risk of CV death is similar to individuals without diabetes with prior MI.1 Although hyperglycemia is a strong risk factor for microvascular complications, it is a weak risk factor for CV disease (CVD), and intervent...
متن کاملThe effects of GLP-1 analogues, DPP-4 inhibitors and SGLT2 inhibitors on the renal system
Diabetic nephropathy (DN) affects an estimated 20%-40% of patients with type 2 diabetes mellitus (T2DM). Key modifiable risk factors for DN are albuminuria, anaemia, dyslipidaemia, hyperglycaemia and hypertension, together with lifestyle factors, such as smoking and obesity. Early detection and treatment of these risk factors can prevent DN or slow its progression, and may even induce remission...
متن کاملRenoprotective effects of garlic
R an article published, entitled “renoprotective effect of aged garlic extract in streptozotocin-induced diabetic rats” (1). In this study, diabetic rats were feed by aged garlic juice orally. The serum and urinary biochemical parameters were analyzed in all the groups and at the end of 12 weeks follow up, the kidney morphological examination were performed, too. They found that, diabetic rats ...
متن کاملSGLT2 Inhibitors and the Diabetic Kidney.
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease worldwide. Blood glucose and blood pressure control reduce the risk of developing this complication; however, once DN is established, it is only possible to slow progression. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, the most recent glucose-lowering oral agents, may have the potential to exert nephroprotectio...
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ژورنال
عنوان ژورنال: Romanian Journal of Diabetes Nutrition and Metabolic Diseases
سال: 2019
ISSN: 2284-6417
DOI: 10.2478/rjdnmd-2019-0010